The recent series of articles in the journal devoted to building a dynamic network model of cerebral ische-mia provides a refreshing perspThe recent series of articles in the journal devoted to building a dynamic network model of cerebral ische-mia provides a refreshing perspective in the field of acute stroke.(DeGracia 2010a; DeGracia 2010b; DeGracia 2010c; DeGracia 2010d) The complexity of this model may be so advanced that few may appre-ciate the details yet this conceptual approach is truly innovative, providing a great example of what may be currently lacking in the field. The author takes an in-trospective viewpoint on the chronicle of colossal ef-forts that have aimed to extend effective therapies for acute ischemic stroke. Altogether the articles evoke a key question on progress in translating stroke re-search to the bedside: Are the answers to combating cerebral ischemia buried amidst the tremendous data amassed in prior studies and trials to date, yet we have failed to recognize the solutions?ective in the field of acute stroke.(DeGracia 2010a; DeGracia 2010b; DeGracia 2010c; DeGracia 2010d) The complexity of this model may be so advanced that few may appre-ciate the details yet this conceptual approach is truly innovative, providing a great example of what may be currently lacking in the field. The author takes an in-trospective viewpoint on the chronicle of colossal ef-forts that have aimed to extend effective therapies for acute ischemic stroke. Altogether the articles evoke a key question on progress in translating stroke re-search to the bedside: Are the answers to combating cerebral ischemia buried amidst the tremendous data amassed in prior studies and trials to date, yet we have failed to recognize the solutions?