A heart transplant, or a cardiac transplant, may be a surgical transplant procedure performed on patients with end-stage coronary failure or severe arteria coronaria disease when other medical or surgical treatments have failed. As of 2018, the foremost common procedure is to require a functioning heart, with or without both lungs, from a recently deceased donor (brain death is that the standard) and implanting it into the patient. The patient's own heart is either removed or replaced with the donor heart (orthotopic procedure) or, much less commonly, the recipient's diseased heart is left in situ to support the donor heart (heterotopic, or "piggyback", transplant procedure).

Approximately 3,500 heart transplants are performed annually worldwide, quite half which are within the US. Post-operative survival periods average 15 years. Heart transplantation isn't considered to be a cure for heart disease; rather it's a life-saving treatment intended to enhance the standard and duration of life for a recipient