In the present work a central transition metal cation (Ferrous sulphate) was selected where curcumin acts as ligand which ultimately give a chelate that is formed with enolic form of curcumin and because curcumin having anti-inflammatory activity, so a novel curcumin metal complex was synthesized with establishing their characterization spectrophotometrically and also in-vitro anti-inflammatory activity has been measured with comparing with the pure curcumin.