Polymers are the backbone of a transdermal drug delivery system as they control the release of the drug from the device. Biodegradable polymers attracts the attention of its use as they can be degraded to non-toxic monomers and most important, a constant rate of drug release can be achieved from a biodegradable polymer based controlled release device. Natural polymers can be used as the means of achieving predetermined rates of drug delivery and their physico-chemical characteristics with the ease of availability provide a platform to use it as a polymer for transdermal drug delivery systems. These polymers may be used to formulate various controlled and targeted drug delivery system.