Joint arthroplasty failure is primarily caused by Periprosthetic Joint Infection (PJI). PJI treatment may result in serious complications, such as Vertebral Osteomyelitis (VO). Risk factors for the development of metachronous VO after PJI, and the outcomes of these patients, are unknown. We aimed to 1) Identify the risk factors for developing meta-chronous VO following PJI and 2) Investigate the clinical outcomes of meta-chronous VO following PJI.